Differential effects of speed and volume on transfusion-associated circulatory overload: A randomized study in rats.
Robert B KlandermanMarije WijnbergeJoachim J BosboomJoris J T H RoelofsDirk de KorteRobin van BruggenMarkus W HollmannMargreeth B VroomDenise P VeeloNicole P JuffermansBart F GeertsAlexander P J VlaarPublished in: Vox sanguinis (2021)
Transfusion volume dose-dependently increased LVEDP, with speed of transfusion rapidly elevating LVEDP at higher transfusion volumes. ANP and NT-proBNP were not impacted by transfusion volume or speed in this model. TACO is seen as purely volume overload, however, this study emphasizes that limiting transfusion speed, as a modifiable risk factor, might aid in preventing TACO.