Identifying underlying medical causes of pediatric obesity: Results of a systematic diagnostic approach in a pediatric obesity center.
Lotte KleinendorstOzair AbawiBibian van der VoornMieke H T M JongejanAnnelies E BrandsmaJenny A VisserElisabeth F C van RossumBert van der ZwaagMariëlle AldersElles M J BoonMieke M van HaelstErica L T van den AkkerPublished in: PloS one (2020)
To our knowledge, this is the first study to report the results of a systematic diagnostic workup aimed at identifying endocrine, genetic, cerebral or medication-induced causes of pediatric obesity. We found that a variety of singular underlying causes were identified in 19% of the patients with severe childhood obesity. Because of this heterogeneity, an extensive diagnostic approach is needed to establish the underlying medical causes and to facilitate disease-specific, patient-tailored treatment.
Keyphrases
- insulin resistance
- healthcare
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- case report
- subarachnoid hemorrhage
- drug induced
- adipose tissue
- early onset
- genome wide
- gene expression
- smoking cessation
- diabetic rats
- blood brain barrier
- oxidative stress
- combination therapy
- adverse drug
- replacement therapy