Investigating the Mechanisms of Pollen Typhae in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking.
Rongrong ZhouDe JinYuqing ZhangLiyun DuanYuehong ZhangYingying DuanXiaomin KangFengmei LianPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
The active ingredients in PT may regulate the levels of inflammatory factors, suppress the oxidative stress, and inhibit the proliferation, migration, and invasion of retinal pericytes by acting on PTGS2, AKT1, VEGFA, MAPK3, TNF, and EGFR targets through VEGF signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, and HIF-1 signaling pathway to play a therapeutic role in diabetic retinopathy.
Keyphrases
- signaling pathway
- diabetic retinopathy
- pi k akt
- induced apoptosis
- optical coherence tomography
- molecular docking
- oxidative stress
- epithelial mesenchymal transition
- cell cycle arrest
- cell proliferation
- small cell lung cancer
- endothelial cells
- molecular dynamics simulations
- ischemia reperfusion injury
- cell death
- vascular endothelial growth factor
- endoplasmic reticulum stress
- combination therapy
- optic nerve