HLA-DPB1 is associated with ANCA-associated vasculitis in children.

Kristen M GibsonBritt I DrögemöllerDirk FoellSusanne M BenselerJinko GrahamRobert E W HancockRaashid A LuqmaniDavid A CabralKelly L BrownColin J Rossnull null

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Similar to previous findings in adult AAV, we found that the HLA-DPB1 locus is associated with pediatric AAV. Despite the difference in the age of onset, these findings suggest that childhood- and adult-onset vasculitis share a common genetic predisposition. The identification of genetic variants contributing to AAV is an important step to improved classification tools and treatment strategies.

Keyphrases

gene therapy
childhood cancer
young adults
machine learning
deep learning
genome wide
early life
bioinformatics analysis