In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa.
Wei Yee ChanManouchehr KhazandiElizabeth E HickeyStephen W PageDarren J TrottPeter B HillPublished in: Veterinary dermatology (2018)
N-acetylcysteine, Tris-EDTA and disodium EDTA have intrinsic antimicrobial activity and represent promising adjuvants that could be used to enhance the efficacy of existing antibiotics against Gram-negative and multidrug-resistant bacterial infections. These agents could be combined with other antimicrobial agents in a multimodal approach for mixed ear infections in dogs.