The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.

Adrián Plaza Beatriz Merino Nuria Del Olmo Mariano Ruiz-Gayo

Published in: British journal of pharmacology (2019)

CCK-8 stimulates adiponectin production in WAT by acting on CCK2 receptors, through a mechanism involving both Akt and PPARγ. Moreover, CCK-8 actions are only observed in the presence of insulin. Our results could have translational value in the design of new insulin-sensitizing therapies.

Keyphrases

insulin resistance
adipose tissue
type diabetes
metabolic syndrome
glycemic control
high fat diet
oxidative stress
signaling pathway
cell proliferation
skeletal muscle