IL-17A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy.

Juanjuan WangLing ZhouHui HouJiao LiXincheng ZhaoJiajie LiJunqin LiXuping NiuRuixia HouKaiming Zhang

Published in: Journal of cosmetic dermatology (2023)

These results showed that IL-17A is involved in angiogenesis and inflammatory response by inhibiting autophagy through AMPK signaling pathway, suggesting that autophagy may be a new therapeutic target for psoriasis.

Keyphrases

signaling pathway
pi k akt
inflammatory response
cell death
endoplasmic reticulum stress
induced apoptosis
epithelial mesenchymal transition
oxidative stress
endothelial cells
lipopolysaccharide induced
atopic dermatitis
immune response
toll like receptor
hidradenitis suppurativa