Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery.

This paper develops theory for bulk acoustic streaming in soft porous materials, with applications to biological tissue. The principal results of this paper are: (i) streaming equations for such porous media, which show interestingly significant differences from those that describe streaming in pure fluids; (ii) the Green functions obtained for these equations in isotropic, infinite media; and (iii) approximate evaluation of the sources in the streaming equations from acoustic wave forms often used, and the streaming velocities and particle trajectories resulting therefrom. People are now investigating acoustic enhancement of delivery of therapeutics such as drug molecules or other particulates, introduced directly into cellular tissue. A comparison of the predictions of the theory in this paper to available data is made and shown to be surprisingly good. Some macroscale effects of the ultrastructure of the tissue that are not contained in the current paper are pointed out for future studies.