F-actin/DRP1 axis-mediated mitochondrial fission promotes mitophagy in diabetic submandibular glands.

Hou-Wei ZhuYi-Ping WangQiu-Fang ZhangKai-Di WangYan Huang Ruo-Lan Xiang

Published in: Oral diseases (2024)

F-actin contributes to HG-evoked mitochondrial fission by interacting with DRP1, which induces mitophagy and impairs mitochondrial function in SMG cells, ultimately damaging the SMG.

Keyphrases

oxidative stress
induced apoptosis
cell cycle arrest
nlrp inflammasome
type diabetes
cell migration
wound healing
cell death
signaling pathway
protein kinase
fluorescent probe