Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells.

Inger Ødum NielsenLine Groth-PedersenJano Dicroce-GiacobiniAnna Sofie Holm JonassenMonika MortensenMesut Bilgin Kjeld Schmiegelow Marja Jäättelä Kenji Maeda

Published in: Metabolomics : Official journal of the Metabolomic Society (2020)

Our study shows that CAD treatment alters balance in the metabolism of glycerophospholipids, and proposes elevation in the levels of lysoglycerophospholipids as part of the mechanism leading to CAD-induced cell death of leukemia cells.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
coronary artery disease
acute myeloid leukemia
bone marrow
pi k akt
signaling pathway
oxidative stress
high glucose
diabetic rats
drug induced
endothelial cells