Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing.

Irene A StaffordFernando H CentenoMayar Al MohajerGeorge ParkersonLaila Woc-ColburnAngelica Janice Burgos-LeeMartha RacJames DunnKenneth Muldrew

Published in: Case reports in obstetrics and gynecology (2020)

Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.

Keyphrases

pregnant women
cell free
circulating tumor
tertiary care
pregnancy outcomes
copy number
preterm birth
circulating tumor cells
genome wide
dna methylation
quantum dots