Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis.
Nicholas S KalsonTim M BrockMassimo ManginoStella M FabianeDerek A MannLee A BorthwickDavid J DeehanFrances M K WilliamsPublished in: PloS one (2018)
These findings suggest that defects in telomere repair contribute to joint fibrosis, and that fibrosis shares a common mechanistic pathway in different organs. Therapeutic strategies to combat telomere shortening may offer novel treatments for fibrotic joint disease.