Extravillous trophoblast invasion accelerated by WNT3A, 5A, and 10B via CD44.

Hironori TakahashiManabu OgoyamaShiho NagayamaHirotada SuzukiAkihide Ohkuchi Shigeki MatsubaraToshihiro Takizawa

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2019)

The present study is the first to show the possibility that WNT3A, WNT5A, and WNT10B exist upstream of CD44 in EVTs. Among them, WNT10B may be a novel accelerator of EVT invasion. WNT signaling mediated by multiple WNT ligands may contribute to EVT invasion.

Keyphrases

cell proliferation
stem cells
nk cells