Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma.
Aurore C A GayMartin BancheroOrestes CarpaijTessa M KoleLeonie ApperlooDjoke van GosligaPutri Ayu FajarGerard H KoppelmanLouis BontRudi W HendriksMaarten van den BergeMartijn C NawijnPublished in: Thorax (2024)
Our results highlight that the response to RSV infection of the bronchial epithelium in asthma and healthy airways was largely similar. However, in asthma, the response of goblet and multiciliated cells is impaired, highlighting the need for studying airway epithelial cells at high resolution in the context of asthma exacerbation.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- induced apoptosis
- allergic rhinitis
- high resolution
- cell cycle arrest
- cystic fibrosis
- endoplasmic reticulum stress
- oxidative stress
- respiratory tract
- cell death
- respiratory syncytial virus
- mass spectrometry
- cell proliferation
- acute respiratory distress syndrome
- mechanical ventilation