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Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.

Wenxue TongYelin ZengDick Ho Kiu ChowWai YeungJiankun XuYujie DengShihui ChenHui ZhaoXiaoling ZhangKevin Kiwai HoLing QinKingston King-Lun Mak
Published in: Annals of the rheumatic diseases (2019)
Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential therapeutic target for OA treatment.
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