Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.
Wenxue TongYelin ZengDick Ho Kiu ChowWai YeungJiankun XuYujie DengShihui ChenHui ZhaoXiaoling ZhangKevin Kiwai HoLing QinKingston King-Lun MakPublished in: Annals of the rheumatic diseases (2019)
Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential therapeutic target for OA treatment.