Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.

Wenxue TongYelin ZengDick Ho Kiu ChowWai YeungJiankun XuYujie DengShihui ChenHui ZhaoXiaoling ZhangKevin Kiwai HoLing QinKingston King-Lun Mak

Published in: Annals of the rheumatic diseases (2019)

Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential therapeutic target for OA treatment.

Keyphrases

cell proliferation
stem cells
signaling pathway
cell death
knee osteoarthritis
induced apoptosis
rheumatoid arthritis
cell therapy
mesenchymal stem cells
risk assessment
climate change
human health
replacement therapy
endoplasmic reticulum stress