Serum Organ-Specific Anti-Heart and Anti-Intercalated Disk Autoantibodies as New Autoimmune Markers of Cardiac Involvement in Systemic Sclerosis: Frequency, Clinical and Prognostic Correlates.
Alida Linda Patrizia CaforioGiacomo De LucaAnna BaritussioMara SegusoNicoletta GalloElisa BisonMaria Grazia CattiniElena PontaraLuna GarganiAlessia PepeCampochiaro CorradoMario PlebaniSabino IlicetoGiovanni PerettoAntonio EspositoLorenzo TofaniAlberto Moggi-PignoneLorenzo DagnaRenzo MarcolongoMarco Matucci-CerinicCosimo BruniPublished in: Diagnostics (Basel, Switzerland) (2021)
The high frequencies of AHA and AIDA suggest a high burden of underdiagnosed autoimmune HInv in SSc. In keeping with the negative prognostic impact of HInv in SSc, AHAs were associated with dismal prognosis.