Effect of hyperthermia and proton beam radiation as a novel approach in chordoma cells death and its clinical implication to treat chordoma.

Prerna SinghJohn EleyAli SaeedBinny BhandaryNayab MahmoodMinjie ChenTijana DukicSina MossahebiDario B RodriguesJaved MahmoodZeljko VujaskovicHem D Shukla

Published in: International journal of radiation biology (2021)

We found that Hyperthermia (HT) combined with Proton Beam Radiation (PBRT) could significantly increase chordoma cell death by activating the death receptor pathway and apoptosis which has the promise to treat metastatic chordoma.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
pi k akt
endoplasmic reticulum stress
signaling pathway
oxidative stress
small cell lung cancer
squamous cell carcinoma
monte carlo
electron microscopy
artificial intelligence