Cell-free DNA levels are increased in acute graft-versus-host disease.

Anna KroezeAnne S CornelissenM Fernanda PascuttiMyrddin VerheijIngrid BulderSjoerd KlarenbeekAicha Ait SoussanMette D HazenbergErfan NurC Ellen van der SchootCarlijn VoermansSacha S Zeerleder

Published in: European journal of haematology (2022)

We show increased cfDNA both in an aGvHD mouse model and in aGvHD patients. We also demonstrate that donor hematopoietic cells and to a lesser degree (damaged) host cells are the cellular source of cfDNA in aGvHD. We propose that nucleosomes and cfDNA might be an additive marker for aGvHD.

Keyphrases

induced apoptosis
mouse model
cell cycle arrest
end stage renal disease
chronic kidney disease
ejection fraction
endoplasmic reticulum stress
signaling pathway
hepatitis b virus
pi k akt