Acetaminophen toxicity in rat and mouse hepatocytes in vitro.

Otto KuceraRené EndlicherDavid RychtrmocHalka LotkováOndřej SobotkaZuzana Cervinková

Published in: Drug and chemical toxicology (2016)

APAP displayed dose-dependent toxicity in hepatocytes of both species. Mouse hepatocytes in primary culture however had approximately three-fold higher susceptibility to the toxic effect of APAP when compared to rat hepatocytes.

Keyphrases

liver injury
oxidative stress
drug induced