Metabolomics-based pharmaceutical evaluation of different parts of Swertia chirayita (Roxb.) Buch.-Ham. ex C.B. Clarke from the western Himalayas.
Devesh TewariSweta BawariSaurabh T MishraPawan GuptaAryalaxmi MZoltán CziákyJózsef JekoIrina LazarovaMuhammad Imran TousifPublished in: Journal of separation science (2024)
Swertia species are common ingredients in numerous herbal remedies. It is also used to treat a wide range of illnesses and possess diverse therapeutic activities. The aim of the study is to elucidate the comprehensive metabolomics profile of Swertia chirayita and the role of various extraction methods in the phytochemical compositions of the extracts of S. chirayita, and their antioxidant and enzyme inhibitory activities. Extraction of the stems, leaves, and flowering tops of S. chirayita was performed by maceration, infusion, and soxhlation using methanol and water as solvent. Extracts were subjected to phytochemical profiling by a liquid-chromatographic system. Antioxidant and enzyme inhibitory activity was carried out. The metabolomics profiling showed that a diverse range of specialized metabolites were present in the stems and leaves & flowering tops of the plant. All the extracts showed substantial antioxidant and enzyme inhibitory activities further confirmed by molecular docking studies. This study appraised the use of S. chirayita aerial parts as a potential antioxidant and its therapeutic application in various chronic illnesses including Alzheimer's disease, diabetes, and other skin-related disorders.
Keyphrases
- molecular docking
- oxidative stress
- mass spectrometry
- anti inflammatory
- type diabetes
- cardiovascular disease
- single cell
- low dose
- molecular dynamics simulations
- metabolic syndrome
- ms ms
- cognitive decline
- palliative care
- south africa
- risk assessment
- soft tissue
- high resolution
- weight loss
- adipose tissue
- mild cognitive impairment
- plant growth
- cell wall