Nocturnal hypercapnia with daytime normocapnia in patients with advanced pulmonary arterial hypertension awaiting lung transplantation.
Yoshinari NakatsukaToyofumi Chen-YoshikawaHideyuki KinoshitaAkihiro AoyamaHiroyasu KuboKimihiko MuraseSatoshi HamadaHirofumi TakeyamaTakuma MinamiNaomi TakahashiKiminobu TanizawaTomohiro HandaToyohiro HiraiHiroshi DateKazuo ChinPublished in: PloS one (2020)
Nocturnal hypercapnia was prevalent among advanced PAH patients who were waiting for lung transplantation, and associated with %TLC. Nocturnal hypercapnia was associated with the increase in cardiac output, which might potentially worsen pulmonary hypertension especially during sleep. Further studies are needed to investigate hemodynamics during sleep and to clarify whether nocturnal hypercapnia can be a therapeutic target for PAH patients.
Keyphrases
- sleep quality
- pulmonary arterial hypertension
- pulmonary hypertension
- obstructive sleep apnea
- blood pressure
- pulmonary artery
- sleep apnea
- depressive symptoms
- end stage renal disease
- physical activity
- extracorporeal membrane oxygenation
- newly diagnosed
- ejection fraction
- prognostic factors
- peritoneal dialysis
- polycyclic aromatic hydrocarbons
- patient reported outcomes
- patient reported