Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams.

Yi ZhengTing-Ting ZhangWen-Bo Shen

Published in: Organic & biomolecular chemistry (2021)

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Keyphrases

room temperature
quantum dots
hydrogen peroxide
electron transfer
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visible light