White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells.

Sunny Hoi-Sang YeungRalph Hon-Sun LeeGerald Wai-Yeung ChengIris Wai-Ting MaJulia KoflerCandice KentFulin MaKarl HerrupMyriam FornageKen AraiKai-Hei Tse

Published in: bioRxiv : the preprint server for biology (2024)

TRIM47, top genetic risk factor for white matter hyperintensity formation, is a negative regulator of autophagy in brain endothelial cells and implicates a novel cellular mechanism for age-related cerebrovascular changes.

Keyphrases

white matter
endothelial cells
multiple sclerosis
cell death
endoplasmic reticulum stress
genome wide
signaling pathway
oxidative stress
risk factors
high glucose
copy number
transcription factor
resting state
blood brain barrier