Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening.

Minzhuo LiuXueqian HuangQi LiuXujie LiMiao ChenYuqiu ZhuXiao-Qing Chen

Published in: Phytochemical analysis : PCA (2019)

Notably, compounds 2-5 were reported in the Potentilla kleiniana Wight et Arn for the first time. The results indicated that the proposed method could be applied for the rapid screening and preparative separation of α-glucosidase inhibitors from a complex matrix.

Keyphrases

high speed
mass spectrometry
liquid chromatography
atomic force microscopy
ms ms
molecular docking
tandem mass spectrometry
high resolution
simultaneous determination
high performance liquid chromatography
multiple sclerosis
solid phase extraction