Population pharmacokinetic model of irinotecan and its metabolites in patients with metastatic colorectal cancer.
Esther Oyaga-IriarteAsier InsaustiOnintza SayarAzucena AldazPublished in: European journal of clinical pharmacology (2019)
CPT-11, SN-38, and SN-38-G can be correctly described by the multicompartmental model presented in this work. As far as we know, it is the first time that a joint model for CPT-11, SN-38, and SN-38-G that includes the process of reconversion from SN-38-G to SN-38 is characterized.
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