Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson's disease.
Mathilde SadocThomas ClairembaultEmmanuel CoronChristian BerthomierSéverine Le DilyFabienne VavasseurAlbane PavageauErik K St LouisYann PéréonMichel NeunlistPascal DerkinderenLaurène Leclair-VisonneauPublished in: Sleep (2023)
Colonic PASH is strongly associated with widespread brain sleep and wake dysfunction, suggesting an extensive diffusion of the pathologic process in PD. Visual and automated analyses of polysomnography signals provide useful markers to gauge covert brain dysfunction in PD.
Keyphrases
- oxidative stress
- resting state
- white matter
- physical activity
- sleep quality
- obstructive sleep apnea
- functional connectivity
- deep learning
- neoadjuvant chemotherapy
- high throughput
- squamous cell carcinoma
- radiation therapy
- multiple sclerosis
- lymph node
- depressive symptoms
- locally advanced
- quantum dots
- rectal cancer
- brain injury
- sensitive detection