Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset.

Marco PuthenparampilAntonio ZitoGiorgia PantanoLisa FederleErica StropparoSilvia MianteGiustina De SilvestroMario PlebaniPaolo Gallo

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)

In RRMS, increased TFH/TFR ratio associates with abnormal IgG production in blood and CSF, suggesting that antibody-producing cells, derived from deregulated peripheral germinal center reaction, colonize the CNS.

Keyphrases

multiple sclerosis
induced apoptosis
cell cycle arrest
chemotherapy induced
endoplasmic reticulum stress
cell proliferation