Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
Fleur L WartonChristopher D MoltenoChristopher M R WartonPia WintermarkNadine M LindingerNeil C DodgeLilla ZölleiAndre J W van der KouweR Colin CarterJoseph L JacobsonSandra W JacobsonErnesta M MeintjesPublished in: Alcoholism, clinical and experimental research (2021)
High-dose choline supplementation during pregnancy mitigated PAE-related regional volume reductions, with larger volumes associated with improved 12-month recognition memory. These results provide the first evidence that choline may be neuroprotective against PAE-related brain structural deficits in humans.