High-Throughput Drug Screening and Multi-Omic Analysis to Guide Individualized Treatment for Multiple Myeloma.
David G CoffeyAndrew J CowanBret DeGraaffTimothy J MartinsNiall CurleyDamian J GreenEdward N LibbyRebecca SilbermannSylvia ChienJin DaiAlicia MoralesTed A GooleyEdus H WarrenPamela S BeckerPublished in: JCO precision oncology (2021)
In patients with relapsed or refractory MM, we demonstrate the feasibility of ex vivo drug sensitivity testing on isolated plasma cells from patient bone marrow biopsies or extramedullary plasmacytomas to inform the next line of therapy.