S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium.

Nienke J T van KootenArjen B BlomIris J Teunissen van ManenWessel F TheeuwesJohannes RothMark A J GorrisBirgitte WalgreenAnnet W SloetjesMonique M HelsenElly L VittersPeter L E M van LentSander KoëterPeter M van der KraanThomas VoglMartijn H J van den Bosch

Published in: Rheumatology (Oxford, England) (2024)

Chronic S100A8/A9 exposure during monocyte-to-macrophage differentiation favours differentiation towards a M2-like macrophage phenotype. The properties of these cells could help explain the catabolic/anabolic dualism in established OA joints with low-grade inflammation.

Keyphrases

low grade
adipose tissue
high grade
induced apoptosis
dendritic cells
oxidative stress
endothelial cells
cell cycle arrest
knee osteoarthritis
pi k akt