Retinal Changes in Double-Antibody Seronegative Neuromyelitis Optica Spectrum Disorders.
Frederike Cosima OertelHanna Gwendolyn ZimmermannSeyedamirhosein MotamediCharlotte BereuterLuca Magdalena MantheyFereshteh AshtariRahele KafiehAlireza DehghaniMohsen PouraziziLekha PanditAnitha D'CunhaOrhan AktasPhilipp AlbrechtMarius RingelsteinElena Hernandez Martinez-LapiscinaBernardo F Sanchez DalmauPablo VillosladaNasrin AsgariRomain MarignierÁlvaro Cobo-CalvoLetizia LeocaniMarco PisaMarta RadaelliJacqueline PalaceAdriana Roca-FernandezMaria Isabel S LeiteSrilakshmi SharmaJérôme de SèzeThomas SengerMichael R YeamanTerry J SmithLawrence J CookAlexander Ulrich BrandtFriedemann Paulnull nullPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
DN-NMOSD is characterized by severe retinal damage after ON and attack-independent retinal neurodegeneration. Most of the damage occurs during the first ON episode, which highlights the need for better diagnostic markers in DN-NMOSD to facilitate an earlier diagnosis as well as for effective and early treatments. In this study, people with DN-NMOSD presented with homogeneous clinical and imaging findings potentially suggesting a common retinal pathology in these patients.