Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.

Stefano MinistriniFrancesco AndreozziFabrizio MontecuccoSilvia MinettiMaria BertolottoLuca LiberaleGaia Chiara ManninoElena SuccurroVelia CassanoSofia MiceliMaria PerticoneGiorgio SestiAngela SciacquaFederico Carbone

Published in: European journal of clinical investigation (2021)

Neutrophil degranulation is associated with the restrictive/DD echocardiographic pattern in patients with T2DM, but not with the normal pattern and dilative/SD patterns. Neutrophils could have a pivotal role in the pathogenesis of myocardial dysfunction, and particularly diastolic dysfunction, in patients with T2DM.

Keyphrases

left ventricular
ejection fraction
oxidative stress
blood pressure
mitral valve
left atrial
pulmonary hypertension
metabolic syndrome
glycemic control
atrial fibrillation
skeletal muscle
adipose tissue