Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.

Judit RostaMáté TóthNadine FriedrichPéter SánthaGábor JancsóMária Dux

Published in: The journal of headache and pain (2022)

Insulin may activate or sensitize meningeal nociceptors that may lead to enhanced headache susceptibility in persons with increased plasma insulin concentration.

Keyphrases

type diabetes
glycemic control
induced apoptosis
signaling pathway
adipose tissue
insulin resistance
endoplasmic reticulum stress