New Insights into Intestinal Permeability in Irritable Bowel Syndrome-Like Disorders: Histological and Ultrastructural Findings of Duodenal Biopsies.
Selenia MigliettaRaffaele BorghiniMichela RelucentiVeronica SorrentinoRui ChenXiaobo LiFrancesco FaziGiuseppe DonatoGiuseppe FamiliariVincenzo PetrozzaAntonio PicarelliPublished in: Cells (2021)
TEM analysis confirmed damages to the intestinal barrier and defense mechanisms by enterocytes in IBS-like patients, probably linked to low-grade inflammation or adverse reactions triggered by food allergens, heavy metals, or other unknown. On the other hand, our study needs confirmation and further investigations with larger populations to facilitate diagnosis, therapy, and prevention of IBS-like disorders in the future.
Keyphrases
- irritable bowel syndrome
- low grade
- heavy metals
- high grade
- end stage renal disease
- ejection fraction
- newly diagnosed
- oxidative stress
- prognostic factors
- emergency department
- current status
- patient reported outcomes
- health risk
- bone marrow
- climate change
- electronic health record
- smoking cessation
- cell therapy
- replacement therapy