Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation.
Pablo Fernández-GarcíaSiri D TaxeråsMarjorie Reyes-FariasLorena GonzálezAndrea Soria-GondekSilvia PelliteroJordi TarascóPau MorenoLauro SumoyJacqueline M StephensLindsey G YooMaría GalánAdriana IzquierdoGema Medina-GómezLaura HerreroPatricia CorralesFrancesc VillarroyaRubén CereijoDavid Sanchez-InfantesPublished in: European journal of endocrinology (2024)
These results suggest that CLDN1 is a novel marker induced in obesity and differentially expressed in T lymphocytes infiltrated in human vWAT as compared with sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis, and alter homeostasis and promote metabolic disease in obesity.
Keyphrases
- insulin resistance
- adipose tissue
- metabolic syndrome
- weight loss
- oxidative stress
- high glucose
- high fat diet induced
- type diabetes
- diabetic rats
- weight gain
- endothelial cells
- induced apoptosis
- high fat diet
- drug induced
- skeletal muscle
- copy number
- cell cycle arrest
- genome wide
- physical activity
- cell death
- dna methylation
- protein protein
- endoplasmic reticulum stress
- small molecule
- transcription factor
- amino acid
- genome wide identification