Comparison of the efficacy and safety of standard- and high-dose daptomycin: A systematic review and meta-analysis.

Masaru SamuraKeisuke TakadaNaoki HiroseTakenori KurataFumio NagumoMasaki UchidaJunki InoueKoji TanikawaYuki EnokiKazuaki TaguchiKazuaki MatsumotoTakashi UedaShigeru FujimuraHiroshige MikamoYoshio TakesueKotaro Mitsutake

Published in: British journal of clinical pharmacology (2023)

SD daptomycin was associated with significantly lower treatment success than HD in patients with complicated bacteraemia/infective endocarditis. The CPK elevation should be considered in patients treated with high daptomycin doses.

Keyphrases

methicillin resistant staphylococcus aureus
high dose
low dose
staphylococcus aureus
stem cell transplantation
combination therapy