Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections.
Irene MigniniMaria Elena AinoraSilvino Di FrancescoLinda GalassoAntonio GasbarriniMaria Assunta ZoccoPublished in: Cancers (2023)
Colo-rectal cancer (CRC) is undoubtedly one of the most severe complications of inflammatory bowel diseases (IBD). While sporadic CRC develops from a typical adenoma-carcinoma sequence, IBD-related CRC follows different and less understood pathways and its pathophysiological mechanisms were not completely elucidated. In contrast to chronic inflammation, which is nowadays a well-recognised drive towards neoplastic transformation in IBD, only recently was gut microbiota demonstrated to interfere with both inflammation processes and immune-mediated anticancer surveillance. Moreover, the role of microbiota appears particularly complex and intriguing when also considering its multifaceted interactions with multiple environmental stimuli, notably chronic pathologies such as diabetes and obesity, lifestyle (diet, smoking) and vitamin intake. In this review, we presented a comprehensive overview on current evidence of the influence of gut microbiota on IBD-related CRC, in particular its mutual interconnections with the environment.
Keyphrases
- weight loss
- rectal cancer
- oxidative stress
- type diabetes
- metabolic syndrome
- ulcerative colitis
- cardiovascular disease
- physical activity
- public health
- drug induced
- insulin resistance
- magnetic resonance
- weight gain
- risk factors
- late onset
- glycemic control
- early onset
- adipose tissue
- radiation therapy
- body mass index
- skeletal muscle
- squamous cell carcinoma
- climate change
- amyotrophic lateral sclerosis
- high fat diet induced
- amino acid
- life cycle
- contrast enhanced