Inhibition of TRPM8 function by the prostacyclin receptor requires coupling to Gq/11 proteins.

Cosmin TrifAlexandra-Maria BanicaAlexandra ManolacheSorina Andreea AnghelDebora-Elena HuţanuTeodora StratulatRodica BadeaGeorge OpritaTudor SelescuStefana M PetrescuMarco SisignanoStefan OffermannsAlexandru BabesSorin Tunaru

Published in: British journal of pharmacology (2023)

Our results demonstrate that an unusual signaling pathway of IP-R, namely the coupling to Gq/11 proteins, inhibits TRPM8, which may contribute to a better understanding of the role of TRPM8 and IP-R in the regulation of pain and inflammation.

Keyphrases

signaling pathway
room temperature
chronic pain
oxidative stress
pulmonary arterial hypertension
pi k akt
pain management
neuropathic pain
pulmonary hypertension
spinal cord injury
spinal cord
cell proliferation
electron transfer