A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care.
Seth A SharpSamuel E JonesRobert A KimmittMichael N WeedonAnne M HalpinAndrew R WoodRobin N BeaumontSeema KingDavid A van HeelPatricia M CampbellWilliam A HagopianJustine M TurnerRichard D OramPublished in: Alimentary pharmacology & therapeutics (2020)
A single nucleotide polymorphism-based GRS may offer more effective and cost-efficient testing of coeliac disease genetic risk in comparison to HLA-DQ stratification. As a comparatively inexpensive test it could facilitate non-invasive coeliac disease diagnosis but needs detailed assessment in the context of other diagnostic tests and against current diagnostic algorithms.