Arterial Stiffness in Transgender Men Receiving Long-term Testosterone Therapy.
Flávia Siqueira CunhaTania Aparecida Sartori Sanchez BachegaElaine Maria Frade CostaVinicius Nahime BritoLeonardo Azevedo AlvaresValéria Aparecida Costa-HongRenata Gomes Sanches VerardinoMaria Helena Palma SirciliBerenice Bilharinho de MendonçaLuiz Aparecido BortolottoSorahia DomenicePublished in: Journal of the Endocrine Society (2023)
The TM group on long-term treatment with testosterone had higher aging-related aortic stiffening than the control groups. These findings indicate that aortic stiffness might be accelerated in the TM group receiving gender-affirming hormone treatment, and suggest a potential deleterious effect of testosterone on arterial function. Preventive measures in TM individuals receiving testosterone treatment, who are at higher risk for cardiovascular events, are highly recommended.