[Total DNA methylation profile in assessing the MGMT gene promoter status in malignant gliomas].
E I PetrovaS A GalstyanE N TelyshevaMarina RyzhovaPublished in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2023)
gene promoter status based on total DNA methylation profile in patients with malignant gliomas as an alternative to methyl-specific PCR. Our results are consistent with data of other neuro-oncology researchers. Indeed, computational methods like MGMT-STP27 are quite powerful and can be used in scientific and clinical practice to assess prognosis and make decisions about chemotherapy with alkylating agents.