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[Total DNA methylation profile in assessing the MGMT gene promoter status in malignant gliomas].

E I PetrovaS A GalstyanE N TelyshevaMarina Ryzhova
Published in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2023)
gene promoter status based on total DNA methylation profile in patients with malignant gliomas as an alternative to methyl-specific PCR. Our results are consistent with data of other neuro-oncology researchers. Indeed, computational methods like MGMT-STP27 are quite powerful and can be used in scientific and clinical practice to assess prognosis and make decisions about chemotherapy with alkylating agents.
Keyphrases
  • dna methylation
  • genome wide
  • copy number
  • gene expression
  • high grade
  • clinical practice
  • palliative care
  • genome wide identification
  • electronic health record
  • transcription factor
  • big data
  • rectal cancer