Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes.

Hiroshi NomotoLina PeiChiara MontemurroMadeline RosenbergerAllison FurtererGiovanni CoppolaBrian NadelMatteo PellegriniTatyana GurloPeter J ButlerSlavica Tudzarova

Published in: Diabetologia (2019)

The conserved pro-survival HIF1α-mediated injury-response signalling is activated in beta cells in type 1 diabetes and likely contributes to the relatively slow rate of beta cell loss at the expense of early defective glucose-induced insulin secretion.

Keyphrases

type diabetes
induced apoptosis
cell cycle arrest
cardiovascular disease
glycemic control
endoplasmic reticulum stress
endothelial cells
single cell
oxidative stress
transcription factor
signaling pathway
blood glucose
diabetic rats
drug induced
metabolic syndrome
blood pressure
free survival
stress induced