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High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis.

Ya-Shuo ZhaoJianing ZhaoHongyu MaYan HanWeichao XuJie WangYanru CaiXuemei JiaQingzhong JiaQian Yang
Published in: Biomedicines (2023)
Our results showed that the high level of gastric hepcidin induced ferroptosis in the stomach but also inhibited iron absorption in the intestines. Inhibiting hepcidin might be a new strategy for the prevention of CAG in the future.
Keyphrases
  • iron deficiency
  • cell death
  • helicobacter pylori
  • high glucose
  • drug induced
  • helicobacter pylori infection
  • signaling pathway
  • diabetic rats
  • current status
  • oxidative stress