Preferential Hematopoietic Differentiation in Induced Pluripotent Stem Cells Derived From Human Umbilical Cord Arterial Endothelial Cells.

Haiyun Pei Huilin Li Lei XuBowen ZhangHeng ZhangXuetao PeiLiqing LiangXiaoyan XieZeng FanZhou YangXiaoling WangFeiling SongLijuan HeWen Yue Xue-Tao Pei

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Collectively, our data suggest that somatic cell memory may predispose HuA-iPSCs to differentiate more amenably into hematopoietic fate, bringing us closer to generating hematopoietic cell types in vitro from nonhematopoietic tissue for therapeutic applications.

Keyphrases

induced pluripotent stem cells
endothelial cells
umbilical cord
bone marrow
mesenchymal stem cells
single cell
cell therapy
electronic health record
stem cells
machine learning
working memory
dna methylation
high glucose
genome wide