Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation.

Yuanming PanXin WangYuqi HeShuye LinMin ZhuYangjie LiJianxun WangJiheng WangXianzong MaJunfeng XuLang YangGuibin YangJiaqiang HuangYouyong LuJianqiu Sheng

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

Our data suggest that decreasing ATP4B is an indicator for gastric mucosa malignant transformation and GC aggressive phenotype and it plays an inhibitory role in gastric cancer as a tumor suppressor via regulating mitochondrial metabolism and apoptosis pathway.

Keyphrases

oxidative stress
endoplasmic reticulum stress
electronic health record
cell cycle arrest
big data
gas chromatography
mass spectrometry
cell proliferation
high resolution
pi k akt