An enrichment strategy for clinical trials in SPMS.

Marcus Werner Koch Luanne M MetzGary Cutter

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

Our results suggest that it is possible to 'enrich' a trial cohort for expected T25FW worsening events using specific baseline T25FW and EDSS cut-off scores. These analyses inform the selection of inclusion criteria for clinical trials in SPMS.

Keyphrases

clinical trial
phase ii
phase iii
study protocol
open label
double blind