High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.
Liang XiaoSi Brask SonneQiang FengNing ChenZhongkui XiaXiaoping LiZhiwei FangDongya ZhangEven FjæreLisa Kolden MidtbøMuriel DerrienFloor HugenholtzLongqing TangJunhua LiJianfeng ZhangChuan LiuQin HaoUlla Birgitte VogelAlicja MortensenMichiel KleerebezemTine Rask LichtHuanming YangJian WangYingrui LiManimozhiyan ArumugamJun WangLise MadsenKarsten KristiansenPublished in: Microbiome (2017)
The changes in the composition of the gut microbiota were predominantly driven by high-fat feeding rather than reflecting the obese state of the mice. Differences in the abundance of butyrate and propionate producing bacteria in the gut may at least in part contribute to the observed differences in obesity propensity in Sv129 and BL6 mice.