Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation.

Shinji ItohTomoharu YoshizumiKyohei YugawaDaisuke ImaiShohei YoshiyaKazuki TakeishiTakeo ToshimaNoboru HaradaToru IkegamiYuji SoejimaKenichi KohashiYoshinao OdaMasaki Mori

Published in: Hepatology (Baltimore, Md.) (2020)

PD-L1 expression in cancer cells was associated with a poor clinical outcome and vascular formation in patients with HCC. Additionally, the combination of PD-L1 expression with tumor-infiltrating CD8-positive T-cell status enabled further classification of patients based on their clinical outcome. Thus, PD-L1 expression in cancer cells and tumor-infiltrating CD8-positive T-cell status might serve as predictive tissue biomarkers.

Keyphrases

immune response
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
machine learning
prognostic factors
deep learning
dendritic cells
type diabetes
toll like receptor
metabolic syndrome
patient reported