Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.
Breton M AskenJeremy A TannerLawren VandeVredeWilliam G MantyhKaitlin B CasalettoAdam M StaffaroniRenaud La JoieLeonardo IaccarinoDavid Soleimani-MeigooniJulio C RojasRaquel C GardnerBruce L MillerLea T GrinbergAdam L BoxerJoel H KramerGil D RabinoviciPublished in: Neurology (2022)
This study provides Class III evidence that (1) among patients with TES and abnormal Aβ-PET scans, elevated plasma P-tau can differentiate between affected individuals and HCs; (2) low plasma P-tau may help identify patients with TES who do not have Alzheimer; and (3) plasma P-tau181 and P-tau217 are not useful biomarkers of patients with TES who do not have AD.