Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway.
Yuanyang ChenSihao ZhengZhi-Wei WangXin CaiYanjia CheQi WuShun YuanXiaohan ZhongPublished in: Mediators of inflammation (2021)
ART can inhibit maturation of dendritic cells through the endoplasmic reticulum stress signaling pathway, thereby alleviating acute rejection in mice after heart transplantation.
Keyphrases
- endoplasmic reticulum stress
- dendritic cells
- induced apoptosis
- signaling pathway
- immune response
- high fat diet induced
- pi k akt
- regulatory t cells
- epithelial mesenchymal transition
- liver failure
- diffuse large b cell lymphoma
- insulin resistance
- drug induced
- adipose tissue
- type diabetes
- cell proliferation
- oxidative stress
- skeletal muscle
- mechanical ventilation